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KMID : 0043320090320060851
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Archives of Pharmacal Research
2009 Volume.32 No. 6 p.851 ~ p.855
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Four Flavonoids from Echinosophora koreensis and their Effects on Alcohol Metabolizing Enzymes
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Yang Hyun-Ok
Kim Chul-Young
Park Hyun-Bong
Nam Chun-Woo
Sohn Young-Chang
Kwon Hak-Cheol
Choi Eun-Ju
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Abstract
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A new prenylated dihydroflavonol, 3-hydroxy-kenusanone B 1, as well as three other known isoflavanones, sophoronol 2, sophoraisoflavanone A 3 and kenusanone H 4, were isolated from the rhizomes of Echinosophora koreensis. The structures of these compounds were elucidated using spectroscopic analyses that included extensive 2D NMR, optical rotation spectrometry and mass spectrometry. All four flavonoids enhanced the activities of alcohol metabolizing enzymes such as alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) at micromolar concentrations. Sophoronol 2 showed a nine-fold increased activation of alcohol dehydrogenase and aldehyde dehydrogenase than a negative control group at concentrations of 100 μg/mL and 50 μg/mL, respectively. This study suggests that prenylated flavonoids have the potential to prevent ‘hangovers’ after alcohol intake.
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KEYWORD
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Echinosophora koreensis, Flavonoids, 3-Hydroxy-kenusanone B, Alcohol dehydrogenase (ADH), Aldehyde dehydrogenase (ALDH)
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